Jeffrey D. Macklis' laboratory is directed toward the cellular repair of complex cerebral cortex and cortical output circuitry (including cortico-spinal motor neuron circuitry). The lab focuses on neural precursor / "stem cell" biology, neocortical projection neuron differentiation, functional neuronal circuit repair via transplantation, and induction of neurogenesis by molecular manipulation of endogenous neural precursors / stem cells within murine neocortex. Since 2002, he has been Director of the newly established MGH-HMS Center for Nervous System Repair. He is also Program Head, Neuroscience/Nervous System Diseases, Harvard Stem Cell Institute and Co-Director for the Regeneration and Repair Program of the Harvard Center for Neurodegeneration and Repair. He attended M.I.T., HMS, and graduate school at M.I.T. within the Harvard-M.I.T. Division of Health Sciences and Technology (HST). He was a postdoc in developmental neuroscience with Richard Sidman at HMS. He trained clinically in Internal Medicine at BWH and adult neurology in the Harvard-Longwood Neurological Training Program. Until moving to MGH in 2003 to establish the new MGH-HMS Center for Nervous System Repair, he was in the basic science Division of Neuroscience at Children's Hospital Boston.