Research Overview
My general research interest lies in cortical repair
and plasticity. During my Ph.D at the Brain Research
Institute of the University of Zurich, I studied
the role of glutamate transporters in ischemic brain
injury. Later, as a resident in the Department of
Clinical Neurosciences of the Geneva University Hospital,
I became interested in clinical aspects of brain injury and recovery
after lesion. I joined the lab in 2004.
Previous work in our lab has shown that the adult
neocortex can be driven to produce new neurons and
that transplanted neuronal precursors can adequately
integrate neocortical circuitry. More recently, the
lab has been able to isolate near-pure populations
of cortical projection neurons using FACS sorting,
enabling the identification of lineage-specific genes in distinct populations of cortical projection
neurons. Together, these two findings put forth the
possibility of cellular repair by fate manipulation
of neuronal precursors.
Together with Dr. Tina Lai, a postdoc in the lab,
I am currently characterizing one of these recently
identified genes, which is preferentially
expressed in corticospinal motor neurons. Using knock-out
mice and over-expression techniques as well as immunocytochemical
and in situ hibridization techniques, we are deciphering
the role of the gene product during cortical development.
In a distinct research project, I am attempting
to identify genes that are critical for the development
and plasticity of the somatosensory cortex. During
the first few postnatal days, neurons located in
layer IV of the somatosensory cortex cluster around
developing thalamocortical afferents and form barrel-like
structures. The molecular mechanisms guiding this
process are unknown and the extent to which it is
driven by thalamocortical activity is still unclear.
Using FACS-purified thalamocortical neurons isolated
from the ventrobasalis nucleus, I am studying the
stage-specific gene expression of this cell population
in animals with altered and normal sensory inputs,
with the purpose of identifying of critical determinants
of barrel cortex development and plasticity.
Key Recent Publications
- Lai, T.*, Jabaudon, D.*, Molyneaux, B.J.‡, Azim, E.‡, Arlotta, P., Menezes, J.R.L., Macklis, J.D. 2008. "SOX5 Controls the Sequential Generation of Distinct Corticofugal Neuron Subtypes." Neuron 57: 232-247. (*equally contributing first authors, ‡equally contributing second authors). pdf
- Arlotta, P.*, Molyneaux, B.J.*, Jabaudon, D., Yoshida, Y., Macklis, J.D. 2008. "Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum." J. Neurosci 28(3): 622-632. (*equally contributing first authors). pdf
Previous Publications
- Ortigue S, Jabaudon D, Landis T, Michel CM, Maravita A, Blanke O. Preattentive interference between touch and audition: a case study on multisensory alloesthesia. Neuroreport 2005 May 31;16(8):865-8.
- Vulliemoz S, Raineteau O, Jabaudon D. Reaching beyond the midline: why are human brains cross wired? Lancet Neurol. 2005 Feb;4(2):87-99.
- Jabaudon D, Sztajzel J, Sievert K, Landis T, Sztajzel R. Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute stroke and transient ischemic attack. Stroke 2004 Jul;35(7):1647-51.
- Jabaudon D, Sztajzel R. Spontaneous carotid artery dissection.Neurology. 2004 Jan 27;62(2):281.
- Arnth-Jensen N, Jabaudon D, Scanziani M. Cooperation between independent hippocampal synapses is controlled by glutamate uptake. Nature Neurosci. 2002 Apr;5(4):325-31.
- Jabaudon D, Scanziani M, Gahwiler BH, Gerber U. Acute decrease in net glutamate uptake during energy deprivation.
PNAS 2000 May 9;97(10):5610-5.
- Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, Gahwiler BH, Gerber U. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. PNAS 1999 Jul 20;96(15):8733-8.
- Fiumelli H, Jabaudon D, Magistretti PJ, Martin JL. BDNF stimulates expression, activity and release of tissue-type plasminogen activator in mouse cortical neurons. Eur J Neurosci. 1999 May;11(5):1639-46.
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